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Test Code CRY_S Cryoglobulin, Serum

Important Note

Heart Center, Redmond FC and Redmond 4th street:

  • Keep blood wrapped in a warm (not hot just warm) glove of water
  •  Please treat the specimen as a STAT and take it over to your hospital lab
  • Bend Specimen Processing or Redmond Lab will continue to incubate the specimen, centrifuge and aliquot for testing

Bend East, Crossroads, Bend South, Sisters, and La Pine:

  • Please allow specimen to clot room temp for 1 hour
  • Centrifuge and aliquot in an appropriately labeled plastic vial
  • Per Mayo specimens are acceptable and can clot at ambient temperature if no warming block is available at your site.

Additional Codes

Internal / External / Beaker: LAB5139

Reporting Name

Cryoglobulin, S

Useful For

Evaluating cryoglobulins in patients with vasculitis, glomerulonephritis, and lymphoproliferative diseases

 

Evaluating cryoglobulins in patients with macroglobulinemia or myeloma in whom symptoms occur with cold exposure

 

This test is not useful for general screening of a population without a clinical suspicion of cryoglobulinemia.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IMFXC Immunofixation Cryoglobulin No No

Testing Algorithm

If cryoglobulin has a positive result after 1 or 7 days, then immunofixation will be performed at an additional charge. Positive cryoglobulins of 0.1 mL or above of precipitate will be typed once.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum Red


Ordering Guidance


This test is also available as a part of a profile to assess for both cryofibrinogen and cryoglobulin. For more information see CRGSP / Cryoglobulin and Cryofibrinogen Panel, Serum and Plasma.



Specimen Required


Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 5 mL

Collection Instructions:

1. Tube must remain at 37° C.

2. Allow blood to clot at 37° C.

3. Centrifuge at 37° C. Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable. It is very important that the specimen remain at 37° C until after separation of serum from red blood cells.

4. Place serum into an appropriately labeled plastic vial.

Additional Information: Analysis cannot be performed with less than 3 mL of serum. Smaller volumes are insufficient to detect clinically important trace (mixed) cryoglobulins. Less than 3 mL will require collection and submission a new specimen.


Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred)
  Frozen 

Reference Values

Negative (positives reported as percent or trace amount) 

If positive after 1 or 7 days, immunotyping of the cryoprecipitate is performed at an additional charge.

Day(s) Performed

Monday through Friday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82595

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRY_S Cryoglobulin, S 12201-0

 

Result ID Test Result Name Result LOINC Value
2684 Cryoglobulin, S 12201-0

Report Available

2 to 10 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Method Name

CRY_S: Quantitation and Qualitative Typing Precipitation
IMFXC: Immunofixation

Secondary ID

80988

Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.